Arginine-containing tripeptide Pro-Arg-Gly is involved in the regulation of the function of anticoagulation and insular systems under persistent hyperglycemia.

Abstract

Intranasal administration of regulatory peptide PRG to rats against the background of persistent hyperglycemia improves blood antiplatelet and anticoagulant-fibrinolytic potential and normalizes blood sugar in comparison with the corresponding parameters in control animals that did not receive the peptide. The fibrinolytic and antiplatelet activities of blood plasma remained elevated 6 days after peptide withdrawal against the background of unchanged glucose administration.

• Authors: L A Andreeva, N F Myasoedov, T A Shubina, M E Grigorieva, L A Ljapina
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 5 Pg. 651-4 (Sep 2012) ISSN: 1573-8221 [Electronic] United States
• PMID: 23113248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Dipeptides
• Fibrinolytic Agents
• Oligopeptides
• Platelet Aggregation Inhibitors
• prolylglycine
• Factor XII
• Arginine
• Tissue Plasminogen Activator
• Glucose

Topics

• Administration, Intranasal
• Animals
• Arginine (chemistry, pharmacology)
• Blood Glucose (analysis)
• Diabetes Mellitus, Experimental (drug therapy, physiopathology)
• Diabetes Mellitus, Type 2 (drug therapy, physiopathology)
• Dipeptides (chemistry)
• Factor XII (metabolism)
• Fibrinolysis (drug effects)
• Fibrinolytic Agents (administration & dosage, chemistry, pharmacology)
• Glucose (administration & dosage)
• Male
• Oligopeptides (administration & dosage, chemistry, pharmacology)
• Partial Thromboplastin Time
• Platelet Aggregation Inhibitors (administration & dosage, chemistry, pharmacology)
• Rats
• Tissue Plasminogen Activator (metabolism)