Abstract | AIMS: METHODS AND RESULTS: We followed 9026 participants in the Atherosclerosis Risk in Communities (ARIC) study without cardiovascular disease at baseline (visit 4, 1996-99). We compared the associations of apoB, apoA-1, and their respective lipoprotein cholesterol measures with incident CHD events among individuals with and without obesity, the metabolic syndrome, or diabetes. Over a median follow up of 10.1 years, there were 903 CHD events. Among participants with obesity, the top quintiles of apoB (HR 2.00, 95% CI 1.40-2.85 compared with the bottom quintile) and the apoB/ apoA-1 ratio (HR 2.47, 95% CI 1.53-4.01) did not demonstrate stronger associations with CHD than the top quintiles of non- high-density-lipoprotein cholesterol (non-HDL-C) (HR 2.54, 95% CI 1.65-3.89) and the ratio of non-HDL-C/HDL-C (HR 4.28, 95% CI 2.29-8.03). Analogous findings were seen among patients with diabetes and the metabolic syndrome. In models adjusted for non-HDL-C and HDL-C, apoB (p = 0.94) and apoA-1 (p = 0.55) were not significantly associated with CHD events among those with obesity, in contrast to non-HDL-C and HDL-C (p = 0.02 for both). CONCLUSIONS:
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Authors | Chiadi E Ndumele, Kunihiro Matsushita, Brad Astor, Salim S Virani, Samia Mora, Emma K Williams, Ron C Hoogeveen, Roger S Blumenthal, A Richey Sharrett, Christie M Ballantyne, Josef Coresh |
Journal | European journal of preventive cardiology
(Eur J Prev Cardiol)
Vol. 21
Issue 7
Pg. 866-75
(Jul 2014)
ISSN: 2047-4881 [Electronic] England |
PMID | 23109406
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | © The European Society of Cardiology 2012. |
Chemical References |
- Apolipoproteins
- Lipoproteins
- lipoprotein cholesterol
- Cholesterol
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Topics |
- Apolipoproteins
(blood)
- Cholesterol
(blood)
- Cohort Studies
- Coronary Disease
(blood, etiology)
- Female
- Follow-Up Studies
- Humans
- Insulin Resistance
- Lipoproteins
(blood)
- Male
- Metabolic Syndrome
(blood, complications)
- Middle Aged
- Obesity
(blood, complications)
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
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