Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus.

Abstract

BACKGROUND:

Monkeys with insulin-dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long-term vascular complications associated with diabetes until the graft function recovered completely. However, the effect of multiple daily injections of porcine or human insulin and the long-term effects of porcine insulin have not been studied in diabetic rhesus monkeys.

METHODS:

Diabetic rhesus monkeys, using a 6-month self-control insulin comparison experiment, were used to detect the incidence of adverse events and long-term diabetes complication events after long-term administration of porcine insulin.

RESULTS:

In this study, we found that a 20% higher dose of porcine insulin results in similar glycemic control as the human insulin regimen, and adverse events were seldom reported when porcine insulin was administered. Moreover, long-term injection with porcine insulin could delay the rate and severity of diabetes-related complications.

CONCLUSIONS:

Porcine insulin as a competent candidate for regular insulin therapy to maintain blood glucose levels in insulin-dependent diabetic monkeys during preclinical studies of islet transplantation.

• Authors: Xi Jin, Li Zeng, Shuang Zhang, Sirong He, Yan Ren, Younan Chen, Lingling Wei, Li Wang, Hongxia Li, Jingqiu Cheng, Yanrong Lu
• Journal: Journal of medical primatology (J Med Primatol) Vol. 42 Issue 1 Pg. 1-9 (Feb 2013) ISSN: 1600-0684 [Electronic] Denmark
• PMID: 23106308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin, Regular, Human
• Insulin, Regular, Pork
• Insulin, Isophane

Topics

• Animals
• Blood Glucose
• Diabetes Mellitus, Experimental (drug therapy)
• Diabetes Mellitus, Type 1 (drug therapy, veterinary)
• Diabetic Nephropathies
• Diabetic Retinopathy
• Glycated Hemoglobin
• Hypoglycemic Agents (adverse effects, economics, therapeutic use)
• Insulin, Isophane (adverse effects, economics, therapeutic use)
• Insulin, Regular, Human (adverse effects, economics, therapeutic use)
• Insulin, Regular, Pork (adverse effects, economics, therapeutic use)
• Macaca mulatta
• Monkey Diseases (drug therapy)