Risk factors for contrast induced nephropathy: a study among Italian patients.

Abstract

This study aimed to make a profile of patients at highest risk of developing contrast induced nephropathy (CIN) in order to take appropriate prevention measures. 591 patients undergoing coronary procedures were divided into two groups: patients with (CIN-group) and without (no-CIN) an increase in creatinine level equal or more than 25% from baseline values within 24-48 h after the coronary procedure. All patients underwent an accurate anamnesis, objective exam, hematochemical measurements, and diagnostic exams. The results of this study while confirming that, average age (p = 0.01), diabetes mellitus (p < 0.0001), base line renal insufficiency (p = 0.0001), diuretic therapy (p = 0.002), higher contrast doses (p = 0.01), are associated with a higher risk of contrast-induced nephropathy, also demonstrated that both clinical (p = 0.01) and subclinical (p < 0.0001) atherosclerosis, and higher preprocedural high sensitive C-reactive protein levels (hs- CRP) (p = 0.02) are risk factors for CIN.

• Authors: Salvatore Evola, Monica Lunetta, Francesca Macaione, Giuseppe Fonte, Gaspare Milana, Egle Corrado, Francesca Bonura, Giuseppina Novo, Enrico Hoffmann, Salvatore Novo
• Journal: Indian heart journal (Indian Heart J) 2012 Sep-Oct Vol. 64 Issue 5 Pg. 484-91 ISSN: 0019-4832 [Print] India
• PMID: 23102387 (Publication Type: Journal Article)
• Copyright: Copyright © 2012. Published by Elsevier B.V.

Chemical References

• Biomarkers
• Contrast Media
• Creatinine

Topics

• Aged
• Biomarkers (blood)
• Chi-Square Distribution
• Contrast Media (adverse effects)
• Coronary Angiography (adverse effects)
• Creatinine (blood)
• Female
• Humans
• Italy
• Kidney Diseases (blood, chemically induced, diagnosis, prevention & control)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Percutaneous Coronary Intervention (adverse effects)
• Risk Assessment
• Risk Factors
• Time Factors
• Up-Regulation