The triblock copolymers hydrogel through intracameral injection may be a new potential ophthalmic drug delivery with antiscarring drugs after glaucoma filtration surgery.

Abstract

The hyperplasia of fiber cell at operation area cause scarring lead to the failure after glaucoma filtration surgery. People are looking for more safe and effective way to advance the success rate in operation. There are many researches demonstrated that ophthalmic drug delivery system can be a treatment. Among this, some biodegradable and thermosensitive triblock copolymers hydrogel are novel candidate for ocular drug release system. But whether they can be used to restrain the hyperplasia of fiber cell through intracameral injection after glaucoma filtration surgery, the research have not been reported. So it suggested a new hypothesis for intracameral injection of the triblock copolymers hydrogel as a new potential in situ sustained ophthalmic drug delivery system with antiscaring formation after glaucoma filtration surgery. Indicating that the new nanomaterials through intracameral injection treating complication of glaucoma filtration surgery is hoped to be a creative and promising ophthalmic drug delivery system in the future.

• Authors: Yu Qiao, Gang Qin, Ling Yu
• Journal: Medical hypotheses (Med Hypotheses) Vol. 80 Issue 1 Pg. 23-5 (Jan 2013) ISSN: 1532-2777 [Electronic] United States
• PMID: 23098373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Hydrogel, Polyethylene Glycol Dimethacrylate

Topics

• Administration, Ophthalmic
• Cicatrix (prevention & control)
• Drug Delivery Systems (methods)
• Glaucoma (surgery)
• Glaucoma Drainage Implants
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use)
• Hyperplasia (drug therapy)
• Models, Biological