Oxidative stress plays an important role in the development of
atherosclerosis. Excess visceral adipose tissue (VAT) and increased carotid intima-media thickness (IMT) are risk factors for
coronary artery disease. We tested the hypothesis that VAT and IMT were associated with systemic oxidative stress. Healthy men and women (n = 565) matched for ethnicity (Aboriginal, Chinese, European, and South Asian) were recruited. Plasma
malondialdehyde, a
biomarker of oxidative stress, was measured as
thiobarbituric acid reactive substances (
TBARS). VAT and IMT were determined by computerized tomography and ultrasound scans, respectively. Plasma
TBARS levels correlated with VAT and total
atheroma burden (sum of IMT area and plaque area) in the entire cohort. When stratified by ethnicity, plasma
TBARS levels correlated with distinct body composition and arterial measures in different ethnic populations with more associations present amongst Chinese and Europeans relative to Aboriginals and South Asians. VAT was associated with plasma
TBARS levels independent of age, sex, ethnicity, smoking, and body mass index. Plasma
TBARS levels were associated with IMT, the presence of plaques, and total
atheroma burden, independent of age, sex, ethnicity, smoking, body mass index, and VAT. The association with total
atheroma burden remained significant even when adjusted for
apolipoprotein B. Results from the present study indicate that oxidative stress is positively associated with VAT as well as diffuse and focal
carotid atherosclerosis in apparently healthy men and women.