A multimineral natural product from red marine algae reduces colon polyp formation in C57BL/6 mice.
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| Abstract |
The goal of this study was to determine if a multimineral natural product derived from red marine algae could reduce colon polyp formation in mice on a high-fat diet. C57BL/6 mice were maintained for up to 18 mo either on a high-fat "Western-style" diet or on a low-fat diet (AIN 76A), with or without the multimineral-supplement. To summarize, colon polyps were detected in 22 of 70 mice (31%) on the high-fat diet but in only 2 of 70 mice (3%) receiving the mineral-supplemented high-fat diet (P < 0.0001). Colon polyps were detected in 16 of 70 mice (23%) in the low-fat group; not significantly different from high-fat group but significantly higher than the high-fat-supplemented group (P = 0.0006). This was in spite of the fact that the calcium level in the low-fat diet was comparable to the level of calcium in the high-fat diet containing the multimineral-product. Supplementation of the low-fat diet reduced the incidence to 8 of 70 mice (11% incidence). Taken together, these findings demonstrate that a multimineral natural product can protect mice on a high-fat diet against adenomatous polyp formation in the colon. These data suggest that increased calcium alone is insufficient to explain the lower incidence of colon polyps.
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| Authors | Muhammad N Aslam, Ingrid Bergin, Madhav Naik, Tejaswi Paruchuri, Anna Hampton, Muneeb Rehman, Michael K Dame, Howard Rush, James Varani |
| Journal | Nutrition and cancer (Nutr Cancer) Vol. 64 Issue 7 Pg. 1020-8 ( 2012) ISSN: 1532-7914 [Electronic] United States |
| PMID | 23035966 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
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