Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary.

Abstract

The nuclear DNA content and S-phase fraction of 23 ovarian granulosa cell tumors were measured from paraffin-embedded tissue with flow cytometry. Crude survival of the patients with a euploid tumor (17 diploid, one tetraploid) was more favorable than that of the patients with an aneuploid tumor (n = 5, P = 0.02). The percentage of S-phase cells was a good predictor of survival. If more than 6% S-phase cells were present in the DNA histogram, both crude survival (P = 0.0001) and survival corrected for intercurrent deaths (P = 0.0001) were clearly inferior as compared with tumors with less than 6% S-phase cells. The results indicate that DNA flow cytometric study may provide a rapid and valuable method to predict the biological behavior of granulosa cell tumors of the ovary.

• Authors: P J Klemi, H Joensuu, T Salmi
• Journal: Cancer (Cancer) Vol. 65 Issue 5 Pg. 1189-93 (Mar 01 1990) ISSN: 0008-543X [Print] United States
• PMID: 2302667 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Neoplasm

Topics

• Adult
• Aged
• DNA, Neoplasm (analysis)
• Female
• Flow Cytometry
• Granulosa Cell Tumor (genetics, mortality, pathology)
• Humans
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (genetics, mortality, pathology)
• Ploidies
• Prognosis
• Recurrence
• Survival Analysis