Abstract |
The aim of this study was to evaluate the correlation between the clinical motor phenotypes of Parkinson's disease (PD) and ¹²³I- MIBG myocardial uptake. In total, 53 patients with PD [31 males and 22 females, mean age 62±10 years; 19 Hoehn & Yahr (H&Y) stage 1, 9 stage 1.5, 15 stage 2 and 10 at stage 3] were examined and subdivided into different clinical forms on the basis of dominance of resting tremor (n=19, TDT) and bradykinesia plus rigidity (n=34, ART). This status was correlated with the semi-quantitative analysis of ¹²³I- MIBG myocardial uptake. An age-matched control group of 18 patients was recruited (8 males and 10 females, mean age 62.4±16.3 years). ¹²³I- MIBG myocardial uptake significantly correlated with disease duration in early (r²=0.1894; P=0.0028) and delayed images (r²=0.1795; P=0.0037) in PD patients, while no correlation was found when considering age at examination, UPDRS III motor examination section score and H&Y score. PD patients showed a reduced ¹²³I- MIBG myocardial uptake compared to the control group in early (P=0.0026) and delayed images (P=0.0040), and ¹²³I- MIBG myocardial uptake was significantly lower in delayed images in TDT patients compared with ART patients (P=0.0167). A decrease was detected in the heart-to-mediastinum (H/M) ratio in delayed images compared to that of the early images in TDT patients (P=0.0040) and in the whole PD population (P=0.0012), while no differences were found in ART patients (P=0.1043). The results of the present study revealed that the cardiac sympathetic system is more severely impaired in TDT than in ART patients and ¹²³I- MIBG molecular imaging has the potential help in improving therapeutic planning in these patients.
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Authors | A Chiaravalloti, A Stefani, M Tavolozza, M Pierantozzi, D Di Biagio, E Olivola, B Di Pietro, M Stampanoni, R Danieli, G Simonetti, P Stanzione, O Schillaci |
Journal | Molecular medicine reports
(Mol Med Rep)
Vol. 6
Issue 6
Pg. 1337-42
(12 2012)
ISSN: 1791-3004 [Electronic] Greece |
PMID | 23023866
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Iodine Radioisotopes
- Radiopharmaceuticals
- 3-Iodobenzylguanidine
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Topics |
- 3-Iodobenzylguanidine
(chemistry)
- Age Factors
- Aged
- Female
- Heart
(physiopathology)
- Humans
- Hypokinesia
(pathology)
- Iodine Radioisotopes
(chemistry)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Myocardium
(metabolism)
- Parkinson Disease
(diagnostic imaging, physiopathology, surgery)
- Radionuclide Imaging
- Radiopharmaceuticals
(chemistry)
- Severity of Illness Index
- Sympathectomy
- Tremor
(pathology)
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