Abstract | BACKGROUND: METHODS: Forty-eight patients who started with anti-TNF-α therapy were compared with a non-treated group of 32 patients. Plasma ADMA and L-arginine were assessed at baseline, 3 and 12 months. In a subgroup of 55 patients, aortic pulse wave velocity (aPWV) was measured at baseline, 3 and 12 moths, and CIMT was examined at baseline and 12 months. RESULTS: Anti-TNF-α therapy increased the L-arginine/ADMA ratio (mean [SD]) in the treatment group compared to the control group after 3 months (12 [29] vs. -13 [20], P < 0.001) and 12 months (7 [27] vs. -8 [19], P = 0.008), but did not affect ADMA (3 months: 0.00 [0.09] μmol/L vs. 0.02 [0.07] μmol/L, P = 0.42, 12 months: 0.01 [0.08] μmol/L vs. 0.01 [0.09] μmol/L, P = 0.88). Baseline aPWV was associated with ADMA (P = 0.02) and L-arginine/ADMA (P = 0.02) in multiple regression analyses, and the L-arginine/ADMA ratio was continuously associated with aPWV after initiation of anti-TNF-α therapy (P = 0.03). ADMA and L-arginine/ADMA were not correlated with CIMT. CONCLUSION: Anti-TNF-α therapy improved the L-arginine/ADMA ratio in patients with inflammatory arthropathies. ADMA and the L-arginine/ADMA ratio were associated with aPWV, and might have a mechanistic role in the aortic stiffening observed in these patients.
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Authors | Kristin Angel, Sella Aarrestad Provan, Petter Mowinckel, Ingebjørg Seljeflot, Tore Kristian Kvien, Dan Atar |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 225
Issue 1
Pg. 160-5
(Nov 2012)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 23014354
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antirheumatic Agents
- Tumor Necrosis Factor-alpha
- N,N-dimethylarginine
- Arginine
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Topics |
- Adult
- Antirheumatic Agents
(therapeutic use)
- Aorta
(physiology)
- Arginine
(analogs & derivatives, blood)
- Arthritis, Psoriatic
(drug therapy)
- Arthritis, Rheumatoid
(drug therapy)
- Blood Pressure
- Carotid Intima-Media Thickness
- Female
- Humans
- Male
- Middle Aged
- Pulse Wave Analysis
- Spondylitis, Ankylosing
(drug therapy)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Vascular Stiffness
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