Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.

Abstract

We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of antibiotic treatment (P = 0.007).

• Authors: Soo Jin Yoo, Hyo-Bin Kim, Sang-Ho Choi, Sang-Oh Lee, Sung-Han Kim, Sang-Bum Hong, Heungsup Sung, Mi-Na Kim
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 56 Issue 12 Pg. 6393-6 (Dec 2012) ISSN: 1098-6596 [Electronic] United States
• PMID: 23006753 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Macrolides
• RNA, Ribosomal, 23S
• DNA

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Child
• Child, Preschool
• Community-Acquired Infections (drug therapy, genetics, microbiology)
• DNA (genetics)
• Drug Resistance, Bacterial (genetics)
• Female
• Humans
• Infant
• Macrolides (pharmacology, therapeutic use)
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Mutation
• Mycoplasma pneumoniae (drug effects, genetics)
• Nasopharynx (microbiology)
• Pneumonia, Mycoplasma (drug therapy, genetics, microbiology)
• Polymerase Chain Reaction
• RNA, Ribosomal, 23S (genetics)
• Young Adult