Abstract | CONTEXT: OBJECTIVE: DESIGN: This was a prospective, case-controlled, observational study. SUBJECTS: Participants were 24 healthy boys with Klinefelter syndrome between 4 and 14 yr of age. Data from sex-, age-, and height-matched healthy controls were obtained from subjects participating in a previously described study. RESULTS: Plasma levels of NTproBNP and CNP were lower, whereas levels of NTproCNP were higher in boys with Klinefelter syndrome compared with published reference ranges. In addition, CNP levels were lower and NTproCNP levels higher than in sex-, age-, and height-matched controls. CONCLUSIONS: In contrast to plasma NTproBNP, CNP production and clearance are increased in boys with Klinefelter syndrome. Together these findings argue against an interaction between BNP with CNP in the growth plate. Why CNP peptide levels are altered in Klinefelter syndrome remains to be explored.
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Authors | Robert C Olney, Timothy C R Prickett, Eric A Espiner, Judith L Ross |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 97
Issue 11
Pg. 4206-11
(Nov 2012)
ISSN: 1945-7197 [Electronic] United States |
PMID | 22962429
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- Natriuretic Peptide, C-Type
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Topics |
- Adolescent
- Case-Control Studies
- Child
- Child, Preschool
- Humans
- Klinefelter Syndrome
(blood)
- Male
- Natriuretic Peptide, Brain
(blood)
- Natriuretic Peptide, C-Type
(blood)
- Peptide Fragments
(blood)
- Prospective Studies
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