Abstract | BACKGROUND & AIMS: New-onset diabetes in patients with pancreatic cancer is likely to be a paraneoplastic phenomenon caused by tumor-secreted products. We aimed to identify the diabetogenic secretory product(s) of pancreatic cancer. METHODS: RESULTS: CONCLUSIONS:
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Authors | Gaurav Aggarwal, Vijaya Ramachandran, Naureen Javeed, Thiruvengadam Arumugam, Shamit Dutta, George G Klee, Eric W Klee, Thomas C Smyrk, William Bamlet, Jing Jing Han, Natalia B Rumie Vittar, Mariza de Andrade, Debabrata Mukhopadhyay, Gloria M Petersen, Martin E Fernandez-Zapico, Craig D Logsdon, Suresh T Chari |
Journal | Gastroenterology
(Gastroenterology)
Vol. 143
Issue 6
Pg. 1510-1517.e1
(Dec 2012)
ISSN: 1528-0012 [Electronic] United States |
PMID | 22960655
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Insulin
- RNA, Small Interfering
- Adrenomedullin
- Glucose
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Adrenomedullin
(drug effects, genetics, metabolism)
- Aged
- Animals
- Cell Line, Tumor
- Cells, Cultured
- Diabetes Mellitus, Type 2
(metabolism, pathology)
- Female
- Glucose
(pharmacology)
- Humans
- In Vitro Techniques
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Insulin-Secreting Cells
(drug effects, metabolism, pathology)
- Male
- Mice
- Mice, Nude
- Middle Aged
- Models, Animal
- Pancreas
(metabolism, pathology)
- Pancreatic Neoplasms
(metabolism, pathology)
- RNA, Small Interfering
(pharmacology)
- Rats
- Transplantation, Heterologous
- Up-Regulation
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