Eicosanoid profiling in colon cancer: emergence of a pattern.

Abstract

Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase-2 (COX-2) and 15-lipoxygenase-1 (15-LOX-1) have opposing impacts on colonic tumorigenesis: COX-2 promotes while 15-LOX-1 inhibits colonic tumorigenesis. Advances in liquid chromatography/mass spectrometry have allowed for measurement of various products of oxidative metabolism in a single colonic biopsy specimen. Studies of LOX products in preclinical models and in patients with familial adenomatous polyposis and sporadic colorectal tumorigenesis indicate that LOX pathways are shifted during colonic tumorigenesis and that the main shift is downregulation of 15-LOX-1. This shift occurs during the polyp formation stage and thus offers the opportunity to modulate tumorigenesis early by correcting 15-LOX-1 downregulation.

• Authors: Xiangsheng Zuo, Imad Shureiqi
• Journal: Prostaglandins & other lipid mediators (Prostaglandins Other Lipid Mediat) 2013 Jul-Aug Vol. 104-105 Pg. 139-43 ISSN: 1098-8823 [Print] United States
• PMID: 22960430 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Linoleic Acids
• 13-hydroxy-9,11-octadecadienoic acid
• ALOX15 protein, human
• Arachidonate 15-Lipoxygenase
• Cyclooxygenase 2
• PTGS2 protein, human
• Dinoprostone

Topics

• Adenomatous Polyposis Coli (genetics, metabolism)
• Arachidonate 15-Lipoxygenase (genetics, metabolism)
• Carcinogenesis (genetics, metabolism)
• Colonic Neoplasms (genetics, metabolism)
• Cyclooxygenase 2 (genetics, metabolism)
• Dinoprostone (metabolism)
• Gene Expression Regulation, Neoplastic
• Humans
• Linoleic Acids (metabolism)
• Metabolome (genetics)
• Signal Transduction