Abstract | BACKGROUND: METHODS: RESULTS:
Caspase-3 activity was higher in patients with small liver remnants (22.66±6.57 vs. 12.60±4.06 count per high-power field, p<0.001). Serum markers of hepatocyte injury, when adjusted per gram of liver remnant, were found to be higher in the study group than in the control group (AST: 1.26±0.25 vs. 0.54±0.11 IU g(-1), p<0.001; α-GST: 0.14±0.02 vs. 0.08±0.01 IU g(-1), p<0.001). Tissue caspase-3 expression in the small liver remnant group correlated with both AST and α-GST levels adjusted per gram of liver remnant (r2=0.51, p=0.005 and r2=0.71, p<0.001, respectively). Significant correlations between postoperative portal hypertension and the same markers as well as caspase-3 activity were also demonstrated. CONCLUSION: Liver remnants less than 30% of standard liver weight are much more susceptible to ischemia/reperfusion injury than controls twice the size. Adjustment of serum markers of hepatocyte injury to the liver remnant weight depicts injury more accurately.
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Authors | Kassiani Theodoraki, Nikolaos Arkadopoulos, Constantinos Nastos, Ioannis Vassiliou, Iosifina Karmaniolou, Vassilios Smyrniotis |
Journal | World journal of surgery
(World J Surg)
Vol. 36
Issue 12
Pg. 2895-900
(Dec 2012)
ISSN: 1432-2323 [Electronic] United States |
PMID | 22956015
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Isoenzymes
- Glutathione Transferase
- glutathione S-transferase alpha
- Aspartate Aminotransferases
- Caspase 3
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Topics |
- Aged
- Aspartate Aminotransferases
(blood)
- Biomarkers
(metabolism)
- Case-Control Studies
- Caspase 3
(metabolism)
- Female
- Glutathione Transferase
(blood)
- Hepatectomy
- Humans
- Hypertension, Portal
(enzymology, etiology)
- Isoenzymes
(blood)
- Liver
(anatomy & histology, enzymology, surgery)
- Male
- Middle Aged
- Organ Size
- Postoperative Complications
(enzymology)
- Reperfusion Injury
(diagnosis, enzymology, etiology)
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