Clinical effectiveness and safety of permissive hypercapnia.

Abstract

Experimental and clinical data indicate that ventilator strategies with permissive hypercapnia may reduce lung injury by a variety of mechanisms. Seven randomized controlled trials in preterm neonates suggest that permissive hypercapnia started early, before the initiation of mechanical ventilation (in conjunction with continuous positive airway pressure), followed by prolonged permissive hypercapnia if mechanical ventilation is needed is an alternative to early ventilation and surfactant. Permissive hypercapnia may improve pulmonary outcomes and survival.

• Authors: Julie Ryu, Gabriel Haddad, Waldemar A Carlo
• Journal: Clinics in perinatology (Clin Perinatol) Vol. 39 Issue 3 Pg. 603-12 (Sep 2012) ISSN: 1557-9840 [Electronic] United States
• PMID: 22954272 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Topics

• Bronchopulmonary Dysplasia (prevention & control)
• Humans
• Hypercapnia
• Infant, Newborn
• Infant, Premature
• Respiration, Artificial (methods)
• Respiratory Distress Syndrome, Newborn (therapy)