Abstract | BACKGROUND: It was recently shown that GERD patients have lower impedance baseline (IB) values than healthy controls and, that the esophageal acid exposure time ( AET) correlates with IB levels. GOALS: To explore the sensitivity of IB measurements in NERD patients, responders and non-responders to PPIs, when compared with pH-impedance (MII-pH) variables, and to evaluate whether this variable could represent a marker of GERD symptoms. Reproducibility and inter-observer agreement of IB measurement were also assessed. Study. MII-pH tracings from 44 NERD responders and 22 non-responders were analysed. Ten healthy volunteers underwent the same protocol. IB values were measured at the distal and proximal esophagus. IB was also analysed in a subgroup of patients and in controls with two methods and by two blinded operators. RESULTS: Mean IB values at the distal esophagus were significantly lower in NERD patients than in controls. IB values did not differ between responders and non-responders. Of the 8 responders with negative AET and symptom association probability (SAP), 3 (37.5%) showed IB values lower than controls. IB values in responders with positive and negative SAP were similar (1832 (1596-2068) Ω vs 1667 (1361-1973) Ω, p: n.s.). No differences were found between the IB values measured with the two methods and the inter-observer agreement was good. CONCLUSIONS: IB is a promising and easy to calculate MII-pH variable and appears to increase the sensitivity of MII-pH monitoring. IB values cannot predict PPI response and are not associated with reflux perception in NERD patients.
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Authors | Mentore Ribolsi, Sara Emerenziani, Osvaldo Borrelli, Paola Balestrieri, Maria Chiara Addarii, Tommasangelo Petitti, Michele Cicala |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 47
Issue 11
Pg. 1266-73
(Nov 2012)
ISSN: 1502-7708 [Electronic] England |
PMID | 22954058
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Confidence Intervals
- Electric Impedance
- Esophageal pH Monitoring
- Female
- Gastroesophageal Reflux
(drug therapy, physiopathology, psychology)
- Humans
- Male
- Manometry
- Middle Aged
- Observer Variation
- Proton Pump Inhibitors
(therapeutic use)
- Reproducibility of Results
- Severity of Illness Index
- Statistics, Nonparametric
- Surveys and Questionnaires
- Time Factors
- Young Adult
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