Influence of angiotensin II type 1 receptor-associated protein on prenatal development and adult hypertension after maternal dietary protein restriction during pregnancy.

Abstract

An adverse relationship between suboptimal fetal environments and the development of adult diseases, such as hypertension, type II diabetes, and cardiovascular disease, has been reported in numerous studies. The purpose of this study was to investigate the strain difference of offspring's response to maternal malnutrition during pregnancy and the involvement of the renin-angiotensin system (RAS) in the development of adult hypertension using C57BL/6J (C57) mice and angiotensin II (Ang II) type 1 receptor-associated protein-transgenic (ATRAP-Tg) mice. Pregnant dams were fed an isocaloric diet containing either 20% (normal protein; NP) or 8% (low protein; LP) protein. Birth weight was significantly reduced in C57-LP offspring, but not in ATRAP-Tg-LP offspring. Arterial blood pressure was higher in C57-LP offspring than in the other groups. In contrast, ATRAP-Tg-LP offspring did not show an increase in blood pressure compared with NP offspring. Renal angiotensin II type 1 (AT(1)) receptor expression was not altered by maternal malnutrition, whereas angiotensin II type 2 receptor expression was significantly decreased in C57-LP offspring. In conclusion, these findings suggest that a suboptimal intrauterine environment induces adult hypertension because of an alteration of expression of RAS components, which was partly suppressed by sustained ATRAP overexpression via attenuation of the AT(1) receptor-mediated pathological response.

• Authors: Kana Tsukuda, Masaki Mogi, Jun Iwanami, Li-Juan Min, Fei Jing, Kousei Ohshima, Masatsugu Horiuchi
• Journal: Journal of the American Society of Hypertension : JASH (J Am Soc Hypertens) 2012 Sep-Oct Vol. 6 Issue 5 Pg. 324-30 ISSN: 1878-7436 [Electronic] United States
• PMID: 22951100 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.

Chemical References

• Dietary Proteins
• Receptor, Angiotensin, Type 1

Topics

• Animals
• Arterial Pressure (physiology)
• Birth Weight
• Diet, Protein-Restricted (adverse effects, methods)
• Dietary Proteins (metabolism)
• Female
• Fetal Development (physiology)
• Hypertension (etiology, metabolism)
• Kidney (metabolism)
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Models, Animal
• Pregnancy
• Prenatal Exposure Delayed Effects (metabolism)
• Receptor, Angiotensin, Type 1 (metabolism)
• Renin-Angiotensin System (physiology)