Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.

Abstract	The tumorigenesis of pancreatic cancer is thought to be a complex process. Investigation of the molecular mechanism of pancreatic cancer and exploring the specific markers for early diagnosis and specific targets of therapy is a key point to prevent and treat pancreatic cancer effectively and to improve their prognosis. In this study, expression profiles experiment was performed using Agilent human whole genomic oligonucleotide microarrays with 41,000 genes. Differentially expressed genes related with pancreatic cancer were screened, and analyzed further by GO term analysis and KEGG Pathway analysis. Our results showed that there were 1276 differentially expressed genes associated with pancreatic cancer. 691 genes were up regulated and 585 were down regulated in pancreatic cancer group. The present study confirmed that the occurrence of pancreatic cancer was involved in multiple-gene interaction. In addition, our study found that pancreatic cancer was related to an activation of the mTOR signaling pathway and renal cell carcinoma pathway.
Authors	Chengzhi He, Hua Jiang, Shasha Geng, Haihui Sheng, Xiaoying Shen, Xiaoyan Zhang, Shizhang Zhu, Ximei Chen, Changqing Yang, Hengjun Gao
Journal	International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 5 Issue 6 Pg. 537-46 ( 2012) ISSN: 1936-2625 [Electronic] United States
PMID	22949936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor Neoplasm Proteins MTOR protein, human TOR Serine-Threonine Kinases
Topics	Adenocarcinoma (genetics, pathology) Adult Aged Biomarkers, Tumor (genetics) Databases, Genetic Down-Regulation Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genome-Wide Association Study Humans Male Middle Aged Multigene Family Neoplasm Proteins (genetics) Oligonucleotide Array Sequence Analysis Pancreatic Neoplasms (genetics, pathology) Precancerous Conditions (genetics, pathology) Signal Transduction TOR Serine-Threonine Kinases (genetics) Up-Regulation

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