[Incidence of metabolic syndrome in systemic lupus erythematosus and its influence by glucocorticoids].

Abstract

OBJECTIVE:

To investigate the incidence and correlative factors of metabolic syndrome (MS) in patients with systemic lupus erythematosus (SLE).

METHODS:

A total of 116 SLE patients and 115 controls were enrolled into the study. The incidence of MS, SLE disease activity index (SLEDAI) of patients with SLE combined with MS (MS-SLE) and patients without MS (n-MS-SLE), lupus characteristics, cumulative glucocorticoids, administration dose of glucocorticoids and hydroxychloroquine were compared between SLE group and the control group.

RESULTS:

The incidence of MS of SLE group was obviously higher than that of the control (34.48% vs 14.78%, P < 0.05). The ratios of patients with lower HDL-C, higher TG and higher blood pressure in SLE group (50.86%, 56.03%, 46.55%) were higher than those in the controls (34.78%, 16.52%, 20.00%, all P < 0.05). MS-SLE group had significantly higher mean waist circumference, BMI, systolic blood pressure and diastolic blood pressure and lower HDL-C than n-MS-SLE group (all P < 0.05). No significant difference was found regarding duration of disease, renal involvement, ESR, C-reactive protein,high-sensitivity C-reactive protein, SLEDAI, cumulative and current glucocorticoids use in MS-SLE group and n-MS-SLE group. The ratio of patients taking hydroxychloroquine in n-MS-SLE group was higher than that of MS-SLE group (46.05% vs 15.00%, P < 0.05).

CONCLUSIONS:

Patients with SLE has a higher incidence rate of MS. Hydroxychloroquine may reduce their MS incidence.

• Authors: Sheng-yun Liu, Jin-yan Guo, Lei Zhang, Zhang-suo Liu, Zhao-hui Zheng, Gen-yang Cheng, Guan-min Gao, Xin Zhang, Gui-zhi Liu, Xiao-feng Zeng
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 51 Issue 6 Pg. 441-4 (Jun 2012) ISSN: 0578-1426 [Print] China
• PMID: 22943753 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Glucocorticoids
• Hydroxychloroquine

Topics

• Adolescent
• Adult
• Case-Control Studies
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Hydroxychloroquine (therapeutic use)
• Incidence
• Lupus Erythematosus, Systemic (complications, drug therapy)
• Male
• Metabolic Syndrome (etiology)
• Middle Aged
• Young Adult