Clinical significance of basal-like breast cancer in Chinese women in Heilongjiang province.

Abstract

BACKGROUND:

Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang.

METHODS:

We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value.

RESULTS:

In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE- in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P=0.041).

CONCLUSIONS:

Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.

• Authors: Ying Liu, Qiu-Ying Jiang, Tao Xin, Li Cai, Chang-Hong Zhao
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 6 Pg. 2735-8 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22938450 (Publication Type: Journal Article)

Chemical References

• BMI1 protein, human
• Biomarkers, Tumor
• Keratin-5
• Keratin-6
• Receptors, Estrogen
• Receptors, Progesterone
• Polycomb Repressive Complex 1
• Receptor, ErbB-2

Topics

• Adult
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (diagnosis, metabolism, mortality, pathology)
• China
• Disease-Free Survival
• Female
• Humans
• Keratin-5 (metabolism)
• Keratin-6 (metabolism)
• Polycomb Repressive Complex 1 (biosynthesis)
• Receptor, ErbB-2 (metabolism)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)