Abstract | OBJECTIVE: METHODS: RESULTS: With a 2-cycle induction treatment, 34 (85.0%) patients achieved complete or partial response. Twenty-four patients (60.0%) got downstage, with T downstage in 21 (52.5%) patients and N downstage in 8 (20.0%) patients. Totally 27 patients got surgery after the induction treatment, of them 20 patients (74.1%) preserved organ functions. Four patients' primary tumors (10.0% in all 40 patients and 14.8% in operated 27 patients) showed pathologically complete responses. The toxicity was mild and manageable. The most common grade 3/4 toxicities were neutropenia (5.0%), nausea/ vomiting (2.5%), stomatitis (2.5%) and thrombocytopenia (2.5%). One patient got grade 2 renal insufficiency and one patient got grade 1 skin rash. CONCLUSION: For resectable HNSCC, nimotuzumab plus PF regimen as induction treatment is highly effective for preserving the organ function and the toxicities are well tolerable.
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Authors | Xiao-ying Zhao, Ye Guo, Yong-xue Zhu, Yu Wang, Guo-pei Zhu, Chao-su Hu, Qing-hai Ji |
Journal | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
(Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi)
Vol. 47
Issue 7
Pg. 536-9
(Jul 2012)
ISSN: 1673-0860 [Print] China |
PMID | 22932235
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- nimotuzumab
- Cisplatin
- Fluorouracil
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Squamous Cell
(therapy)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Female
- Fluorouracil
(administration & dosage)
- Head and Neck Neoplasms
(therapy)
- Humans
- Male
- Middle Aged
- Squamous Cell Carcinoma of Head and Neck
- Young Adult
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