Abstract | INTRODUCTION: AREAS COVERED: This paper discusses the mechanism of action, uroselectivity and clinical efficacy/tolerability of Silodosin. Additionally, drug interactions and urodynamic effects are reviewed with a focus on ejaculatory dysfunction. EXPERT OPINION:
Silodosin is a rapidly efficacious and safe agent in the treatment of LUTS/BPH in men. A lack of clinically important cardiovascular side effects makes it of potential use in the elderly. There is a higher risk of ejaculatory dysfunction, which may lead to discontinuation in younger men. The availability of generic counterparts may make this compound less marketable in countries with social healthcare systems.
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Authors | Nadir I Osman, Christopher R Chapple, Francisco Cruz, François Desgrandchamps, Carlos Llorente, Francesco Montorsi |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 13
Issue 14
Pg. 2085-96
(Oct 2012)
ISSN: 1744-7666 [Electronic] England |
PMID | 22924980
(Publication Type: Journal Article, Review)
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Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Indoles
- Receptors, Adrenergic, alpha-1
- silodosin
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
(pharmacology, therapeutic use)
- Drug Interactions
- Humans
- Indoles
(pharmacology, therapeutic use)
- Lower Urinary Tract Symptoms
(drug therapy, etiology)
- Male
- Pharmacovigilance
- Prostatic Hyperplasia
(complications, drug therapy)
- Receptors, Adrenergic, alpha-1
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