Abstract | OBJECTIVES: METHODS: RESULTS: Hepatic tissue expression of GGT and 8-OHdG was seen in ALD, NASH and fatty liver patients. The percentage of hepatocytes positive for 8-OHdG expression and serum 8-OHdG levels was significantly higher in patients with NASH than simple fatty liver. Serum GGT levels were increased in all cases with ALD, NASH and fatty liver, and correlated significantly with serum levels of 8-OHdG in ALD and NASH, but not in simple fatty liver. CONCLUSIONS: Levels of GGT in fatty liver patients may compensate for mild oxidative stress by repressing 8-OHdG levels and preventing progression to NASH; however further oxidative stress leads to increased levels of 8-OHdG and the development of NASH.
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Authors | M Irie, T Sohda, K Iwata, H Kunimoto, A Fukunaga, S Kuno, K Yotsumoto, K Sakurai, H Iwashita, G Hirano, S I Ueda, K Yokoyama, D Morihara, S Nishizawa, A Anan, Y Takeyama, M Sakamoto, S Shakado, S Sakisaka |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 40
Issue 3
Pg. 924-33
( 2012)
ISSN: 1473-2300 [Electronic] England |
PMID | 22906265
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- 8-Hydroxy-2'-Deoxyguanosine
- gamma-Glutamyltransferase
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Aged
- Biomarkers
(blood, metabolism)
- Deoxyguanosine
(analogs & derivatives, blood)
- Fatty Liver
(enzymology, pathology)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Oxidative Stress
- gamma-Glutamyltransferase
(blood, metabolism)
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