Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation.

Abstract

Haploidentical hematopoietic stem cell transplantation is a curative alternative option for patients without an otherwise suitable stem cell donor. In order to prevent graft-versus-host disease (GvHD), different in vitro and in vivo T cell-depletion strategies have been developed. A delayed immune reconstitution is common to all these strategies, and an impaired immune function after haploidentical transplantation with subsequent infections is a major cause of deaths in these patients. In addition to in vitro and in vivo T cell-depletion methods, posttransplant strategies to rapidly rebuild the immune system have been introduced in order to improve the outcome. Advances in in vitro and in vivo T cell-depletion methods, and adoptive transfer of immune cells of the innate and specific immune system, will contribute to reduce the risk of GvHD, lethal infections, and the risk of relapse of the underlying malignant disease.

• Authors: Lena Oevermann, Peter Lang, Tobias Feuchtinger, Michael Schumm, Heiko-Manuel Teltschik, Patrick Schlegel, Rupert Handgretinger
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1266 Pg. 161-70 (Aug 2012) ISSN: 1749-6632 [Electronic] United States
• PMID: 22901267 (Publication Type: Journal Article, Review)
• Copyright: © 2012 New York Academy of Sciences.

Chemical References

• Antigens, CD19
• Antigens, CD34
• CD3 Complex
• Immunosuppressive Agents
• Receptors, Antigen, T-Cell, alpha-beta
• Cyclophosphamide

Topics

• Adoptive Transfer
• Antigens, CD19 (metabolism)
• Antigens, CD34 (metabolism)
• CD3 Complex (metabolism)
• Cyclophosphamide (administration & dosage)
• Graft vs Host Disease (immunology, prevention & control)
• Haplotypes (immunology)
• Hematopoietic Stem Cell Transplantation (methods)
• Hematopoietic Stem Cells (cytology, immunology)
• Humans
• Immunity, Innate
• Immunosuppressive Agents (administration & dosage)
• Lymphocyte Depletion
• Receptors, Antigen, T-Cell, alpha-beta (metabolism)
• T-Lymphocytes (immunology)