Abstract | BACKGROUND: Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size. METHODS: We examined whether htSNPs in IGF-1 and the IGFBP-1/ IGFBP-3 gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age 18 among healthy women from the Nurses' Health Study (NHS) and NHSII. We used ordinal logistic regression to model odds ratios ( ORs) and 95% confidence intervals (CI) of a one category increase for birthweight and somatotypes at ages 5 and 10. We used linear regression to model associations with BMI at age 18. RESULTS: Among 4567 healthy women in NHS and NHSII, we observed no association between common IGF-1 or IGFBP-1/ IGFBP-3 SNPs and birthweight, body fatness at ages 5 and 10, or BMI at age 18. CONCLUSIONS: Common IGF-1 and IGFBP-1/ IGFBP-3 SNPs are not associated with body size in early life.
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Authors | Elizabeth M Poole, Shelley S Tworoger, Susan E Hankinson, Heather J Baer |
Journal | BMC public health
(BMC Public Health)
Vol. 12
Pg. 659
(Aug 15 2012)
ISSN: 1471-2458 [Electronic] England |
PMID | 22894543
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Insulin-Like Growth Factor Binding Protein 1
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
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Topics |
- Adiposity
(genetics)
- Adolescent
- Adult
- Birth Weight
(genetics)
- Body Mass Index
- Body Size
(genetics)
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Humans
- Insulin-Like Growth Factor Binding Protein 1
(genetics)
- Insulin-Like Growth Factor Binding Protein 3
(genetics)
- Insulin-Like Growth Factor I
(genetics)
- Middle Aged
- Polymorphism, Single Nucleotide
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