Abstract | OBJECTIVES: DESIGN AND METHODS: The study involved 194 biopsy-proven NAFLD patients (102 male and 92 female) with a mean age of 51.3±13.8 years. We examined which anthropometric, metabolic and inflammatory variables, and liver steatosis and fibrosis markers are independently associated with serum levels of PEDF. RESULTS: Mean serum levels of PEDF were 16.4±5.7 μg/mL. Univariate analysis revealed that age (inversely), male, body mass index, waist circumference, numbers of white blood cells and platelets, aspartate aminotransferase, alanine aminotransferase, fasting plasma glucose, glycated hemoglobin, uric acid, procollagen type III N-terminal peptide ( P-III-P), subcutaneous fat areas, visceral fat areas and liver to spleen density ratio in computed tomography, the presence of diabetes and medication for hyperlipidemia were significantly associated with serum levels of PEDF. In multiple stepwise regression analysis, age (p<0.01, inversely), male (p<0.05), waist circumference (p<0.01), white blood cell number (p<0.05), P-III-P (p<0.05), and the presence of diabetes (p<0.05) and medication for hyperlipidemia (p<0.01), were independently correlated to serum levels of PEDF (R(2)=0.285). CONCLUSIONS: The present study reveals that serum levels of PEDF are independently associated with P-III-P levels, suggesting that PEDF level is a novel biomarker of liver fibrosis in patients with NAFLD.
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Authors | Hideyuki Hyogo, Sho-ichi Yamagishi, Sayaka Maeda, Yuki Kimura, Tomokazu Ishitobi, Kazuaki Chayama |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 45
Issue 18
Pg. 1554-7
(Dec 2012)
ISSN: 1873-2933 [Electronic] United States |
PMID | 22884488
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Eye Proteins
- Nerve Growth Factors
- Peptide Fragments
- Procollagen
- Serpins
- pigment epithelium-derived factor
- procollagen Type III-N-terminal peptide
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Topics |
- Eye Proteins
(blood)
- Fatty Liver
(blood)
- Female
- Humans
- Male
- Middle Aged
- Nerve Growth Factors
(blood)
- Non-alcoholic Fatty Liver Disease
- Peptide Fragments
(blood)
- Procollagen
(blood)
- Regression Analysis
- Serpins
(blood)
|