The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis.

Abstract

BACKGROUND:

The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with non-alcoholic fatty liver disease and alcoholic liver disease (ALD). This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases.

METHODS:

We enrolled 638 consecutive Japanese patients newly diagnosed with HCC between 2001 and 2010: 72 patients with hepatitis B virus (HBV), 462 with hepatitis C virus (HCV), and 104 with non-B non-C (NBNC).

RESULTS:

NBNC patients exhibited large tumors of advanced TNM stages at HCC diagnosis, and had significantly poorer prognosis than HBV or HCV patients (P < 0.001 and <0.001, respectively; log-rank test). The G/G genotype of PNPLA3 rs738409 SNP had significantly higher distribution in NBNC patients (P < 0.001) and was significantly associated with higher body mass index (BMI) and an increased aspartate aminotransferase to platelet ratio index. No significant differences were observed in survival with differences in PNPLA3 SNP genotypes among the patients, although ALD patients with the G/G genotype of PNPLA3 SNP and low BMI had significantly poorer survival than those with high BMI (P = 0.028).

CONCLUSIONS:

The G/G genotype of PNPLA3 rs738409 SNP was more frequently distributed, and associated with BMI and fibrosis among NBNC-HCC patients but not among HBV or HCV patients. These genotypes might affect HCC prognosis in ALD patients, but not in HBV, HCV, or NAFLD patients.

• Authors: Yasuto Takeuchi, Fusao Ikeda, Yuki Moritou, Hiroaki Hagihara, Tetsuya Yasunaka, Kenji Kuwaki, Yasuhiro Miyake, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhide Yamamoto
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 48 Issue 3 Pg. 405-12 (Mar 2013) ISSN: 1435-5922 [Electronic] Japan
• PMID: 22869157 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Membrane Proteins
• Lipase
• adiponutrin, human

Topics

• Adult
• Aged
• Aged, 80 and over
• Body Mass Index
• Carcinoma, Hepatocellular (diagnosis, genetics, pathology, virology)
• Female
• Follow-Up Studies
• Genotype
• Hepatitis B, Chronic (complications)
• Hepatitis C, Chronic (complications)
• Hepatitis E (complications)
• Humans
• Kaplan-Meier Estimate
• Lipase (genetics)
• Liver Neoplasms (diagnosis, genetics, pathology, virology)
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Neoplasm Staging
• Polymorphism, Single Nucleotide
• Prognosis