RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound.

Abstract

RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone) is a new antiviral compound with activity specific for rhinoviruses. Virus synthesis in R-HeLa cells was susceptible to low concentrations (0.25 micrograms/ml) of the compound. RMI 15,731 was effective if added for 1 h before infection and removed or if added as late as 6 h postinfection. Low concentrations of the compound directly inactivated infectious rhinovirus in a time- and temperature-dependent fashion. RMI 15,731 appears to be a promising new antirhinovirus compound for clinical evaluation since it (i) blocks intracellular virus synthesis (without cellular toxicity), and (ii) directly inactivates virions. The last property may be important in limiting virus shedding from an infected host.

• Authors: R J Ash, R A Parker, A C Hagan, G D Mayer
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 16 Issue 3 Pg. 301-5 (Sep 1979) ISSN: 0066-4804 [Print] United States
• PMID: 228594 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Furans
• RMI 15731

Topics

• Antiviral Agents (metabolism, pharmacology)
• Cell Survival (drug effects)
• Furans (pharmacology)
• HeLa Cells
• Humans
• Rhinovirus (drug effects)
• Temperature