[Lewis lung carcinoma variant with high sensitivity to antitumor antiangiogenic therapy reveals a high capacity to autophagy].

Abstract

Comparative investigation of two variants of Lewis lung carcinoma cells (LLC and LLC/R9) growing under nutrient deficiency caused by long-term incubation without growth medium replacement was performed. It was established that LLC/R9 cells which in contrast to LLC cells had a high sensitivity to antitumor antiangiogenic therapy (AAT) revealed a high dependence of their survival from glucose level in growth medium as well as high capacity to autophagy under nutrient deficiency. Perhaps high autophagy activity in tumor cells may be considered as a marker of tumor AAT sensitivity.

• Authors: D L Kolesnyk, O M Piaskovs'ka, N A Tregubova, H I Solianyk
• Journal: TSitologiia i genetika (Tsitol Genet) 2012 May-Jun Vol. 46 Issue 3 Pg. 33-40 ISSN: 0564-3783 [Print] Ukraine
• PMID: 22856144 (Publication Type: English Abstract, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Biomarkers, Pharmacological
• Culture Media
• Propylamines
• Glucose

Topics

• Angiogenesis Inhibitors (pharmacology)
• Animals
• Autophagy (drug effects)
• Biomarkers, Pharmacological
• Carcinoma, Lewis Lung (drug therapy, pathology)
• Cell Count
• Cell Line, Tumor (drug effects)
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Culture Media
• Glucose (metabolism)
• Mice
• Mice, Inbred C57BL
• Microscopy, Electron
• Organ Specificity
• Propylamines (pharmacology)