Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation.

Abstract

Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.

• Authors: T I Ti, E H Monteiro, S Lam, H S Lee
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 34 Issue 9 Pg. 1809-11 (Sep 1990) ISSN: 0066-4804 [Print] United States
• PMID: 2285296 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Chloramphenicol
• chloramphenicol succinate

Topics

• Administration, Oral
• Adolescent
• Adult
• Child
• Chloramphenicol (administration & dosage, analogs & derivatives, blood, therapeutic use)
• Chromatography, High Pressure Liquid
• Female
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Typhoid Fever (blood, drug therapy)