Background.
Infantile colic is a distressing and common condition for which there is no proven standard treatment. Objective. To compare the efficacy of Mentha piperita with
simethicone in treatment for
infantile colic. Methods. A double-blind crossover study was performed with 30 infants attending IMIP, Recife, Brazil. They were randomized to use Mentha piperita or
simethicone in the treatment of
infantile colic during 7 days with each
drug. Primary outcomes were mother_s opinion about responses to the treatment, number of daily episodes of
colic, and time spent crying, measured by a chronometer. Mann-Whitney and chi-square tests were used to compare the results. This study was previously approved by the Ethical Committee in Research at IMIP. Results. At baseline daily episodes of
infantile colic was 3.9 (±1.1) and the mean crying time per day was 192 minutes (±51.6). At the end of the study daily episodes of
colic fell to 1.6 (±0.6) and the crying duration decreased to 111 (±28) minutes. All mothers reported decrease of frequency and duration of the episodes of
infantile colic and there were no differences between responses to Mentha piperita and
simethicone. Conclusions. These findings suggest that Mentha piperita may be used to help control
infantile colic. However, these results must be repeated by others studies.