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The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro.

Abstract
In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells.
AuthorsTao Xin, Fubin Zhang, Qiuying Jiang, Chunhong Chen, Dayong Huang, Yanju Li, Weixi Shen, Yinghua Jin, Guangjie Sui
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 51 Issue 5 Pg. 788-93 (Dec 2012) ISSN: 1879-0003 [Electronic] Netherlands
PMID22829051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Drug Combinations
  • Hyaluronan Receptors
  • Laminin
  • Polysaccharides
  • Proteoglycans
  • matrigel
  • Collagen
Topics
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Adhesion (drug effects)
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Cell Proliferation (drug effects)
  • Chemical Phenomena
  • Codonopsis (chemistry)
  • Collagen (metabolism)
  • Drug Combinations
  • Female
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Humans
  • Hyaluronan Receptors (metabolism)
  • Laminin (metabolism)
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Ovarian Neoplasms (pathology)
  • Polysaccharides (chemistry, isolation & purification, pharmacology)
  • Proteoglycans (metabolism)

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