Recent advances in neuraminidase inhibitor development as anti-influenza drugs.

Abstract

The recent emergence of the highly pathogenic H5N1 subtype of avian influenza virus (AIV) and of the new type of human influenza A (H1N1) have emphasized the need for the development of effective anti-influenza drugs. Presently, neuraminidase (NA) inhibitors are widely used in the treatment and prophylaxis of human influenza virus infection, and tremendous efforts have been made to develop more potent NA inhibitors to combat resistance and new influenza viruses. In this review, we discuss the structural characteristics of NA catalytic domains and the recent developments of new NA inhibitors using structure-based drug design strategies. These drugs include analogues of zanamivir, analogues of oseltamivir, analogues of peramivir, and analogues of aromatic carboxylic acid and present promising options for therapeutics or leads for further development of NA inhibitors that may be useful in the event of a future influenza pandemic.

• Authors: Enguang Feng, Deju Ye, Jian Li, Dengyou Zhang, Jinfang Wang, Fei Zhao, Rolf Hilgenfeld, Mingyue Zheng, Hualiang Jiang, Hong Liu
• Journal: ChemMedChem (ChemMedChem) Vol. 7 Issue 9 Pg. 1527-36 (Sep 2012) ISSN: 1860-7187 [Electronic] Germany
• PMID: 22807317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Acids, Carbocyclic
• Antiviral Agents
• Cyclopentanes
• Enzyme Inhibitors
• Guanidines
• Oseltamivir
• Benzoic Acid
• Neuraminidase
• Zanamivir
• peramivir

Topics

• Acids, Carbocyclic
• Animals
• Antiviral Agents (chemistry, pharmacology)
• Benzoic Acid (chemistry, pharmacology)
• Cyclopentanes (chemistry, pharmacology)
• Drug Design
• Enzyme Inhibitors (chemistry, pharmacology)
• Guanidines (chemistry, pharmacology)
• Humans
• Influenza A Virus, H1N1 Subtype (drug effects, enzymology)
• Influenza A Virus, H5N1 Subtype (drug effects, enzymology)
• Influenza, Human (drug therapy)
• Models, Molecular
• Neuraminidase (antagonists & inhibitors, chemistry, metabolism)
• Orthomyxoviridae (drug effects, enzymology)
• Orthomyxoviridae Infections (drug therapy)
• Oseltamivir (chemistry, pharmacology)
• Zanamivir (chemistry, pharmacology)