The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

Abstract

There is significant interest in the development of agents that can ameliorate radiation damage after exposure to radiation has occurred. Here we report that chronic supplementation of the antioxidant Tempol in the diet of mice can reduce body weight without toxicity, decrease cancer, and extend survival when administered after nonlethal total body radiation (TBI). These effects were apparent in two different strains of mice (C3H, CBA) exposed to TBI (3 Gy). Notably, delaying administration of the Tempol diet one month after TBI could also enhance survival. Tempol reduced the incidence of hematopoietic neoplasms (lymphomas) in both strains, whereas both the onset and incidence of nonhematopoietic neoplasms were reduced in CBA mice. These results encourage further study of Tempol as a chemopreventive, to reduce the incidence of radiation-induced second malignancies after a course of definitive radiation therapy. Tempol may also find applications to reduce the risk of cancers in populations exposed to nonlethal radiation due to nuclear accidents or terrorist attacks.

• Authors: James B Mitchell, Miriam R Anver, Anastasia L Sowers, Philip S Rosenberg, Maria Figueroa, Angela Thetford, Murali C Krishna, Paul S Albert, John A Cook
• Journal: Cancer research (Cancer Res) Vol. 72 Issue 18 Pg. 4846-55 (Sep 15 2012) ISSN: 1538-7445 [Electronic] United States
• PMID: 22805306 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)

Chemical References

• Antioxidants
• Cyclic N-Oxides
• Radiation-Protective Agents
• Spin Labels
• tempol

Topics

• Animals
• Antioxidants (pharmacology)
• Cyclic N-Oxides (pharmacology)
• Female
• Mice
• Neoplasms, Radiation-Induced (prevention & control)
• Radiation-Protective Agents (pharmacology)
• Spin Labels
• Whole-Body Irradiation (adverse effects)