The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population.

Abstract

BACKGROUND:

Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis.

METHODS:

A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ²) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies.

RESULTS:

Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement.

CONCLUSION:

We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

• Authors: Wei-Chiao Chang, Peng Yeong Woon, Yu-Wen Hsu, Shengyu Yang, Yi-Ching Chiu, Ming Feng Hou
• Journal: TheScientificWorldJournal (ScientificWorldJournal) Vol. 2012 Pg. 916587 ( 2012) ISSN: 1537-744X [Electronic] United States
• PMID: 22778704 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channels
• Genetic Markers
• ORAI1 Protein
• ORAI1 protein, human

Topics

• Adult
• Aged
• Breast Neoplasms (epidemiology, genetics)
• Calcium Channels (genetics)
• Female
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (epidemiology, genetics)
• Humans
• Middle Aged
• ORAI1 Protein
• Polymorphism, Single Nucleotide (genetics)
• Prevalence
• Risk Factors
• Taiwan (epidemiology)