Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.

Abstract	We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.
Authors	Manjeet Bains, Lucía Fernández, Robert E W Hancock
Journal	Applied and environmental microbiology (Appl Environ Microbiol) Vol. 78 Issue 18 Pg. 6762-8 (Sep 2012) ISSN: 1098-5336 [Electronic] United States
PMID	22773629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Bacterial Toxins Phosphates
Topics	Bacterial Toxins (biosynthesis, genetics) Gene Expression Profiling Locomotion Phosphates (metabolism) Pseudomonas aeruginosa (genetics, metabolism, pathogenicity, physiology)

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