Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids.

Abstract

OBJECTIVE:

To examine the effects of topically applied recombinant human insulin-like growth factor 1 (IGF1) via gelatin hydrogels on alterations in pure-tone audiometry (PTA) in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic steroids.

STUDY DESIGN:

Retrospective chart review.

SETTING:

A single university hospital.

PATIENTS:

Twenty-five patients with SSHL refractory to systemic steroids who received topical IGF1 treatment.

INTERVENTION:

Single topical application of IGF1 to the round window niche using gelatin hydrogels.

MAIN OUTCOME MEASURES:

The primary outcome was alterations in PTA thresholds at frequencies of 0.25, 0.5, 1, 2, and 4 kHz after topical IGF1 application. Secondary outcomes included differences in final improvements in PTA thresholds among frequencies tested and cumulative numbers of patients showing 10- or 20-dB recovery in PTA during the observation period.

RESULTS:

Topical IGF1 application via gelatin hydrogels significantly altered PTA thresholds at each frequency tested and at the average frequency. The numbers of patients with a 10-dB recovery in PTA increased until 4 weeks after treatment and then stabilized, whereas those patients showing 20-dB recovery gradually increased during the observation period.

CONCLUSION:

Topical IGF1 application via gelatin hydrogels contributes to the recovery of PTA levels in patients with SSHL refractory to systemic steroids. Major recovery of PTA levels occurs within 4 weeks after treatment.

• Authors: Takayuki Nakagawa, Eriko Ogino-Nishimura, Harukazu Hiraumi, Tastunori Sakamoto, Norio Yamamoto, Juichi Ito
• Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (Otol Neurotol) Vol. 33 Issue 6 Pg. 941-6 (Aug 2012) ISSN: 1537-4505 [Electronic] United States
• PMID: 22772021 (Publication Type: Journal Article)

Chemical References

• Hydrogels
• Recombinant Proteins
• Steroids
• Insulin-Like Growth Factor I

Topics

• Administration, Topical
• Adult
• Aged
• Audiometry, Pure-Tone
• Auditory Threshold (drug effects)
• Drug Resistance
• Female
• Hearing Loss, Sensorineural (drug therapy)
• Hearing Loss, Sudden (drug therapy)
• Humans
• Hydrogels
• Insulin-Like Growth Factor I (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Recombinant Proteins (administration & dosage, therapeutic use)
• Retrospective Studies
• Round Window, Ear
• Steroids (therapeutic use)
• Treatment Outcome
• Young Adult