Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker?

Abstract

Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as mid-regional proadrenomedullin (MR-proADM), a stable peptide of the precursor of adrenomedullin (ADM), responsible for volume regulation and electrolyte homeostasis. Increased levels of MR-proADM are associated with an increased risk of mortality and morbidity in patients with HF, independent of natriuretic peptides. MR-proADM outperforms all other established markers in the identification of patients at highest risk of death, particularly death within 30 days. The prognostic superiority has consistently been shown for various cardiovascular disease states, including acute heart failure. In this article, we discuss the potential role of MR-proADM in the syndrome of acute heart failure and its implication on prognosis and risk stratification.

• Authors: Mihael Potocki, Ronny Ziller, Christian Mueller
• Journal: Current heart failure reports (Curr Heart Fail Rep) Vol. 9 Issue 3 Pg. 244-51 (Sep 2012) ISSN: 1546-9549 [Electronic] United States
• PMID: 22733501 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Biomarkers
• Peptide Fragments
• Protein Precursors
• mid-regional pro-adrenomedullin, human
• Natriuretic Peptide, Brain
• Adrenomedullin

Topics

• Acute Coronary Syndrome (metabolism)
• Acute Disease
• Adrenomedullin (metabolism)
• Biomarkers
• Chronic Disease
• Endothelium, Vascular (metabolism)
• Heart Failure (diagnosis, metabolism, mortality)
• Humans
• Myocardial Infarction (metabolism)
• Natriuretic Peptide, Brain (metabolism)
• Peptide Fragments (metabolism)
• Prognosis
• Protein Precursors (metabolism)
• Vasodilation (physiology)