[Particularities of corrective action of polar lipids and bioantioxidants from sea hydrobionts at imbalances of lipid and carbohydrate metabolism].

Abstract

A total mixture of phospho- and glycolipids from sea macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. Biological activity of the mixtures of polar lipids and natural antioxidants echinochrome A from flat sea urchin Scaphechinus mirabilis and polyphenolic complex from sea grass Zostera marina was studied in rats with experimental model of atherosclerosis and diabetes. These experiments revealed optimal compositions for mixtures of polar lipids and antioxidants, which possess high medical-corrective activity. Proposed mechanisms of action of the polar lipids (containing different polyunsaturated fatty acids) and antioxidants studied are presented. These compositions may be used for creation of new biologically-active additives and drugs.

• Authors: O N Krivoshapko, A M Popov, A A Artiukov, E Ia Kostetskiĭ
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2012 Mar-Apr Vol. 58 Issue 2 Pg. 189-98 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 22724358 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Blood Glucose
• Drug Combinations
• Fatty Acids, Unsaturated
• Lipids
• Naphthoquinones
• Malondialdehyde
• Transaminases
• echinochrome A

Topics

• Animals
• Antioxidants (pharmacology)
• Aquatic Organisms
• Atherosclerosis (drug therapy, metabolism)
• Blood Glucose (metabolism)
• Carbohydrate Metabolism (drug effects)
• Diabetes Mellitus, Experimental (drug therapy, metabolism)
• Disease Models, Animal
• Drug Combinations
• Fatty Acids, Unsaturated (analysis, chemistry, pharmacology)
• Lipid Metabolism (drug effects)
• Lipids (chemistry, isolation & purification, pharmacology)
• Malondialdehyde (metabolism)
• Mice
• Mice, Inbred CBA
• Naphthoquinones (pharmacology)
• Sea Urchins
• Transaminases (metabolism)
• Ulva (chemistry)
• Zosteraceae (chemistry)