Tumour biomarker expression relative to age and molecular subtypes of invasive breast cancer.

Abstract

BACKGROUND:

Quantitative differences in biomarker expression relative to age and molecular subtypes have not been well documented in invasive breast cancer (IBCA).

METHODS:

Oestrogen receptor (ER), progesterone receptor (PR), HER2, ki67, p53 and DNA ploidy was performed by image analysis in 162 consecutive IBCAs in women (≤ 40 years) and compared with women ≥ 50 years (100 cases). Molecular subtypes were defined by immunohistochemistry (IHC).

RESULTS:

Among young women, tumours were frequently ER negative (P=0.01) with lower ER (P<0.00), PR (P=0.03), higher ki67 index (KI) (P=0.01) and p53 (P=0.00) compared with older women. Triple negative was more frequent among young women with frequent lymph node involvement compared with older women. Luminal B among young vs old women showed lower ER (67% vs 88%), PR (32% vs 52%), higher KI (48% vs 34%) and p53 (19% vs 7%). Linear regression model showed increasing KI (P<0.0001) and p53 (P=0.0003) according to the molecular subtypes. Survival difference among subtypes was demonstrated by multivariate analysis (P=0.0092) after adjusting for age, race, tumour size, grade and stage.

CONCLUSION:

We demonstrated significant differences in biomarker expression relative to age and molecular subtypes. Molecular subtype defined by IHC was an independent prognostic factor.

• Authors: D H Morrison, D Rahardja, E King, Y Peng, V R Sarode
• Journal: British journal of cancer (Br J Cancer) Vol. 107 Issue 2 Pg. 382-7 (Jul 10 2012) ISSN: 1532-1827 [Electronic] England
• PMID: 22713661 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Ki-67 Antigen
• Receptors, Estrogen
• Receptors, Progesterone
• TP53 protein, human
• Tumor Suppressor Protein p53
• Receptor, ErbB-2

Topics

• Adult
• Age Factors
• Biomarkers, Tumor (biosynthesis, genetics)
• Breast Neoplasms (genetics, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry (methods)
• Ki-67 Antigen (biosynthesis, genetics)
• Lymphatic Metastasis
• Middle Aged
• Prognosis
• Receptor, ErbB-2 (biosynthesis, genetics)
• Receptors, Estrogen (biosynthesis, genetics)
• Receptors, Progesterone (biosynthesis, genetics)
• Tumor Suppressor Protein p53 (biosynthesis, genetics)