Abstract | BACKGROUND: METHODS: We identified 1397 patients diagnosed with APL between 1975 and 2008 in the Surveillance, Epidemiology, and End Results database. Patients were categorized into 4 age groups and 3 calendar periods. As a comparison, we also reviewed the outcome of APL patients treated at our institution during approximately the same time interval. RESULTS: The incidences of APL increased with time period and patient age. Short- and long-term RS improved with each calendar period, with the greatest improvement occurring between 1991 and 1999; 5-year RS rates were 0.18 for patients diagnosed in 1975-1990, 0.52 in 1991-1999, and 0.64 in 2000-2008. Age was an important predictor of survival. For example, the 5-year RS rate in patients diagnosed in 2000-2008 was 0.38 for patients aged ≥ 60 years and 0.73 and 0.75 for patients aged <20 years and 20-39 years, respectively. Similar treads of improvements in the survival were observed in APL patients treated at our institution. CONCLUSIONS: The incidence of APL has increased, especially in the last decade. Clinical outcome improved remarkably in patients with APL diagnosed from 1991 to 1999, mainly because of the increased use of all-trans retinoic acid.
|
Authors | Yiming Chen, Hagop Kantarjian, Haijun Wang, Jorge Cortes, Farhad Ravandi |
Journal | Cancer
(Cancer)
Vol. 118
Issue 23
Pg. 5811-8
(Dec 01 2012)
ISSN: 1097-0142 [Electronic] United States |
PMID | 22707337
(Publication Type: Journal Article)
|
Copyright | Copyright © 2012 American Cancer Society. |
Chemical References |
- Arsenicals
- Oxides
- Tretinoin
- Arsenic Trioxide
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Arsenic Trioxide
- Arsenicals
(therapeutic use)
- Female
- Humans
- Incidence
- Leukemia, Promyelocytic, Acute
(drug therapy, epidemiology, mortality)
- Male
- Middle Aged
- Oxides
(therapeutic use)
- SEER Program
- Time Factors
- Tretinoin
(therapeutic use)
- United States
|