Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.

Abstract

As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL). Here we report a meta-analysis of three genome-wide association studies on AL conducted in 1,860 Chinese adults, 929 Chinese children, and 2,155 Malay adults. We identified a genetic locus on chromosome 1q41 harboring the zinc-finger 11B pseudogene ZC3H11B showing genome-wide significant association with AL variation (rs4373767, β = -0.16 mm per minor allele, P(meta) =2.69 × 10(-10)). The minor C allele of rs4373767 was also observed to significantly associate with decreased susceptibility to high myopia (per-allele odds ratio (OR) =0.75, 95% CI: 0.68-0.84, P(meta) =4.38 × 10(-7)) in 1,118 highly myopic cases and 5,433 controls. ZC3H11B and two neighboring genes SLC30A10 and LYPLAL1 were expressed in the human neural retina, retinal pigment epithelium, and sclera. In an experimental myopia mouse model, we observed significant alterations to gene and protein expression in the retina and sclera of the unilateral induced myopic eyes for the murine genes ZC3H11A, SLC30A10, and LYPLAL1. This supports the likely role of genetic variants at chromosome 1q41 in influencing AL variation and high myopia.

• Authors: Qiao Fan, Veluchamy A Barathi, Ching-Yu Cheng, Xin Zhou, Akira Meguro, Isao Nakata, Chiea-Chuen Khor, Liang-Kee Goh, Yi-Ju Li, Wan'e Lim, Candice E H Ho, Felicia Hawthorne, Yingfeng Zheng, Daniel Chua, Hidetoshi Inoko, Kenji Yamashiro, Kyoko Ohno-Matsui, Keitaro Matsuo, Fumihiko Matsuda, Eranga Vithana, Mark Seielstad, Nobuhisa Mizuki, Roger W Beuerman, E-Shyong Tai, Nagahisa Yoshimura, Tin Aung, Terri L Young, Tien-Yin Wong, Yik-Ying Teo, Seang-Mei Saw
• Journal: PLoS genetics (PLoS Genet) Vol. 8 Issue 6 Pg. e1002753 ( 2012) ISSN: 1553-7404 [Electronic] United States
• PMID: 22685421 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• Cation Transport Proteins
• Nuclear Proteins
• RNA-Binding Proteins
• SLC30A8 protein, human
• Zc3h11a protein, mouse
• Zinc Transporter 8
• Lysophospholipase
• LYPLAL1 protein, human

Topics

• Adult
• Animals
• Carrier Proteins (genetics)
• Cation Transport Proteins (genetics)
• Child
• China
• Chromosomes, Human, Pair 1 (genetics)
• Disease Models, Animal
• Female
• Gene Expression
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Lysophospholipase (genetics)
• Male
• Mice
• Middle Aged
• Myopia (genetics)
• Nuclear Proteins
• Polymorphism, Single Nucleotide (genetics)
• RNA-Binding Proteins
• Retina (metabolism, pathology)
• Retinal Pigment Epithelium (metabolism)
• Sclera (metabolism, pathology)
• Zinc Transporter 8