Abstract | OBJECTIVE: To determine the frequency and spectrum of myocardial dysfunction in patients with severe sepsis and septic shock using transthoracic echocardiography and to evaluate the impact of the myocardial dysfunction types on mortality. PATIENTS AND METHODS: A prospective study of 106 patients with severe sepsis or septic shock was conducted from August 1, 2007, to January 31, 2009. All patients underwent transthoracic echocardiography within 24 hours of admission to the intensive care unit. Myocardial dysfunction was classified as left ventricular (LV) diastolic, LV systolic, and right ventricular (RV) dysfunction. Frequency of myocardial dysfunction was calculated, and demographic, hemodynamic, and physiologic variables and mortality were compared between the myocardial dysfunction types and patients without cardiac dysfunction. RESULTS: CONCLUSION: Myocardial dysfunction is frequent in patients with severe sepsis or septic shock and has a wide spectrum including LV diastolic, LV systolic, and RV dysfunction types. Although evaluation for the presence and type of myocardial dysfunction is important for tailoring specific therapy, its presence in patients with severe sepsis and septic shock was not associated with increased 30-day or 1-year mortality.
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Authors | Juan N Pulido, Bekele Afessa, Mitsuru Masaki, Toshinori Yuasa, Shane Gillespie, Vitaly Herasevich, Daniel R Brown, Jae K Oh |
Journal | Mayo Clinic proceedings
(Mayo Clin Proc)
Vol. 87
Issue 7
Pg. 620-8
(Jul 2012)
ISSN: 1942-5546 [Electronic] England |
PMID | 22683055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Echocardiography
- Female
- Heart
(physiopathology)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Sepsis
(complications, physiopathology)
- Shock, Septic
(complications, physiopathology)
- Stroke Volume
- Ventricular Dysfunction, Left
(diagnostic imaging, epidemiology, etiology, mortality, physiopathology)
- Ventricular Dysfunction, Right
(epidemiology)
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