Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up.

Abstract

Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease usually having a good prognosis. But the recurrence of uveitis and the chronic progression of kidney injury are still main problems. We report a 15-year-old girl with TINU who showed proteinuria, pathological renal change, multiple organ dysfunction, and immune disorders. After 2 months of 1 mg/kg/day corticosteroid therapy, 24-h urine protein, liver function tests, and creatine kinase returned to normal level. In spite of this, steroid was tapered off slowly and small dose of steroid maintenance therapy lasted for 1 year. Her kidney and ocular symptoms did not recur during 5 years of follow-up. We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome.

• Authors: Letian Zhou, Ying Li, Fuyou Liu, Youming Peng, Yinghong Liu, Jun Li
• Journal: Renal failure (Ren Fail) Vol. 34 Issue 7 Pg. 934-6 ( 2012) ISSN: 1525-6049 [Electronic] England
• PMID: 22681193 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Prednisone

Topics

• Adolescent
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Nephritis, Interstitial (drug therapy)
• Prednisone (therapeutic use)
• Treatment Outcome
• Uveitis (drug therapy)