Abstract | BACKGROUND: METHODS: After confirming severe brain injury involving more than 50% of the ipsilateral hemisphere volume at 1 h after MCAO using diffusion-weighted magnetic resonance imaging (MRI) in postnatal day (P)10 rats, human UCB-derived MSCs were transplanted intraventricularly. The brain MRI was evaluated periodically up to 28 d after MCAO (P38). Sensorimotor function and histology in the peri- infarct tissues were evaluated at the end of the experiment. RESULTS: CONCLUSION: These results suggest that human UCB-derived MSCs are a promising therapeutic candidate for the treatment of severe perinatal brain injury including neonatal stroke.
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Authors | Eun Sun Kim, So Yoon Ahn, Geun Ho Im, Dong Kyung Sung, Ye Rim Park, Seo Hui Choi, Soo Jin Choi, Yun Sil Chang, Wonil Oh, Jung Hee Lee, Won Soon Park |
Journal | Pediatric research
(Pediatr Res)
Vol. 72
Issue 3
Pg. 277-84
(Sep 2012)
ISSN: 1530-0447 [Electronic] United States |
PMID | 22669296
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Animals, Newborn
- Brain Injuries
(prevention & control)
- Immunohistochemistry
- In Situ Nick-End Labeling
- Magnetic Resonance Imaging
- Mesenchymal Stem Cell Transplantation
- Middle Cerebral Artery
(pathology)
- Rats
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