Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: There was a significant fall in concentration of cys-LTs, LTB(4) and 8-isoprostane at visit 3 compared to day 1 (cys-LTs: 196.5 ±38.4 pg/ml vs. 50.1 ±8.2 pg/ml, p < 0.002; LTB(4): 153.6 ±25.5 pg/ml vs. 71.9 ±11.3 pg/ml, p < 0.05; 8- isoprostane: 121.4 ±14.6 pg/ml vs. 56.1 ±5.2 pg/ml, p < 0.03, respectively). Exhaled H(2)O(2) was higher on day 1 compared to that at visits 2 and 3 (0.74 ±0.046 µM vs. 0.52 ±0.028 µM and 0.35 ±0.029 µM, p < 0.01 and p < 0.01, respectively). Exhaled PGE(2) levels did not change during exacerbations of COPD. Exhaled eicosanoids and H(2)O(2) in EBC measured at the follow-up visit (stable COPD) were significantly higher compared to those from healthy subjects. CONCLUSIONS: We conclude that eicosanoids and oxidants are increased in infectious exacerbations of COPD. They are also elevated in the airways of stable COPD patients compared to healthy subjects.
|
Authors | Adam Antczak, Maciej Ciebiada, Tadeusz Pietras, Wojciech J Piotrowski, Zofia Kurmanowska, Paweł Górski |
Journal | Archives of medical science : AMS
(Arch Med Sci)
Vol. 8
Issue 2
Pg. 277-85
(May 09 2012)
ISSN: 1896-9151 [Electronic] Poland |
PMID | 22662001
(Publication Type: Journal Article)
|