[Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats].

Abstract

Intramuscular (i.m.) administration ofdiazepam in a dose of 10 mg/kg and adrenaline in a dose of 0.2 mg/kg prevents generalized clonic-tonic pentylenetetrazol (PTZ) seizures in 75-80 % of rats, but only in 35-40 % of rats it prevents local clonic PTZ seizures. In the above mentioned dose, diazepam causes a strong sedation, but adrenaline does not cause a sedative effects. The combined administration of diazepam and adrenaline in threshold independently ineffective doses prevents both clonic-tonic and clonic PTZ seizures in 80 % of rats without a sedation development. The basis for mechanism of potentiation of anticonvulsant action of diazepam is the stimulation of gastric mucosa afferents by adrenaline.

• Authors: S E Serdiuk, V E Gmiro
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 98 Issue 2 Pg. 236-41 (Feb 2012) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 22650067 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Hypnotics and Sedatives
• Diazepam
• Pentylenetetrazole
• Epinephrine

Topics

• Animals
• Anticonvulsants (administration & dosage)
• Diazepam (administration & dosage)
• Drug Synergism
• Epinephrine (administration & dosage)
• Gastric Mucosa (drug effects)
• Hypnotics and Sedatives
• Injections, Intramuscular
• Male
• Pentylenetetrazole (administration & dosage)
• Rats
• Seizures (chemically induced)
• Visceral Afferents (drug effects)