Comparative study of the outcome of induction of labor using 25 µg and 50 µg of vaginal misoprostol.

Abstract

OBJECTIVE:

To compare the safety and effectiveness of vaginal misoprostol 25 μg with those of 50 μg in induction of labor.

METHOD:

One hundred and sixty eligible women of low parity with indications for induction of labor at term were enrolled for the study. The subjects were randomized into two groups of vaginal misoprostol 25 µg and 50 µg dose regimens. Maternal characteristics, labor and newborn outcome were compared.

RESULTS:

The total duration of labor was significantly shorter in the 50 µg group (8.24 ± 1.5 h) than 25 µg group (9.09 ± 2.7 h), p = 0.02. Oxytocin augmentation was significantly higher in the 25 µg group (18.75%) than in the 50 µg group (7.5%), p = 0.04. The indications for caesarean section were significantly different, (p = 0.02) between the two groups although the incidence was similar. The intrapartum adverse effects like fetal distress, meconium stained liquor, and tachysystole were significantly higher in the 50 µg group, p = 0.003. Similarly, the postpartum adverse effects such as cervical and vaginal tears were significantly higher in 50 µg group, p = 0.01.

CONCLUSION:

The two dose regimens were both effective in induction of labor, but 50 µg dose regimen resulted in significantly shorter duration of labor but with higher rate of labor complications than the 25 µg dose regimen.

• Authors: Olabisi M Loto, Adeniran A Ikuomola, Ibrahim I Ayuba, Uche Onwudiegwu
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 25 Issue 11 Pg. 2359-62 (Nov 2012) ISSN: 1476-4954 [Electronic] England
• PMID: 22640229 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Oxytocics
• Misoprostol

Topics

• Administration, Intravaginal
• Adult
• Algorithms
• Cervix Uteri (drug effects)
• Cesarean Section (statistics & numerical data)
• Dose-Response Relationship, Drug
• Female
• Humans
• Infant, Newborn
• Labor, Induced (adverse effects, methods, statistics & numerical data)
• Misoprostol (administration & dosage, adverse effects, pharmacology)
• Nigeria (epidemiology)
• Oxytocics (administration & dosage, adverse effects, pharmacology)
• Pregnancy
• Pregnancy Outcome (epidemiology)
• Treatment Outcome
• Vagina (drug effects)