[Epidemiologic and tonometric results of a multicenter study of 5,872 patients with ocular hypertension or open-angle glaucoma treated with betaxolol].

Abstract

A large french multicenter study has been conducted by 750 ophthalmologists with 5,872 patients with open angle chronic glaucoma or intraocular hypertension. The patients were treated twice a day for a period of six months with Betaxolol eye drops, a Beta-1 betablocker product, and cardioselective. Concerning the total population of patients, 35% had a cardiovascular systemic context, 12.1% had a pulmonary systemic context, 5.2% were diabetic patients. Efficacy, systemic tolerance, visual comfort have been evaluated during the study, for each group of patient. After six months of treatment, intra-ocular pressure of the 5,872 patients has been lowered from 22.61 mmHg to 18.25 mmHg. Patients have reported a global efficacy in 97% of cases, a good systemic tolerance in 91% of the cases. The investigations have reported a global efficacy in 96% of cases and a good systemic tolerance in 91%. Ocular comfort has been reported as acceptable by 89% patients and by 92% of the Investigators. The analysis of the results of the study allows us to say that the Beta-blocker-Beta-1 selective eye drop, can be used in treatment of intraocular hypertension or open angle chronic glaucoma with a high range of efficacy and safety.

• Authors: H Bourgeois
• Journal: Ophtalmologie : organe de la Societe francaise d'ophtalmologie (Ophtalmologie) 1990 Jul-Aug Vol. 4 Issue 4 Pg. 323-5 ISSN: 0989-3105 [Print] France
• Vernacular Title: Résultats épidémiologiques et tonométriques d'une étude multicentrique portant sur 5,872 patients avec hypertonie oculaire ou glaucome à angle ouvert traités par le bêtaxolol.
• PMID: 2263381 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Betaxolol

Topics

• Betaxolol (therapeutic use)
• Female
• Glaucoma, Open-Angle (drug therapy, epidemiology, physiopathology)
• Humans
• Male
• Middle Aged
• Ocular Hypertension (drug therapy, epidemiology, physiopathology)
• Risk Factors
• Tonometry, Ocular